Glycochenodeoxycholic acid

Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC) . Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) [1][2][3][4].

Product Specifications

CAS Number

[640-79-9]

Product Name Alternative

Chenodeoxycholylglycine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; BCL6; Caspase; Endogenous Metabolite; Interleukin Related; STAT

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Glycochenodeoxycholic_acid.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic) |Methanol : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCC(O)=O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])C[C@H]3O)C)([H])CC1

Molecular Formula

C26H43NO5

Molecular Weight

449.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207 (1-2) :19-27.|[2]Lan W, et al. Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells[J]. Toxicol Lett. 2020 Oct 1;331:11-21. |[3]Wang A, et al. Glycochenodeoxycholic Acid Does Not Increase Transforming Growth Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis in Myofibroblasts[J]. J Clin Exp Hepatol. 2017 Dec;7 (4) :316-320.|[4]Shi C, et al. Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells[J]. Aging (Albany NY) . 2020 Aug 3;12 (15) :15546-15555.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite; Microbial Metabolite

Citation 01

Adv Sci (Weinh) . 2025 Feb 3:e2411719.|Biomolecules. 2025 Jun 28;15 (7) :943. |Discov Oncol. 2023 Jan 11;14 (1) :4.|SSRN. 2022 Jan 26.|Hepatol Int. 2024 Jun;18 (3) :1040-1052.