KT-333

KT-333 is a molecular glues that degrades STAT3 protein. KT-333 mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL) . KT-333 has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1].

Product Specifications

CAS Number

[2502186-79-8]

UNSPSC

12352005

Target

Molecular Glues; STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kt-333.html

Purity

97.43

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@H](C2)NC(C3=CC4=CC(C([P](O)(O)=O)=O)=CC=C4N3)=O)=O)[C@](CCN2C(C)=O)([H])CC1)N[C@@H](CCC(N)=O)COC(C=CC=C5CCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]6O)[C@@H](C6)C(N[C@H](C7=CC=C(C(SC=N8)=C8C)C=C7)C)=O)=O)=O)=C5Cl

Molecular Formula

C60H74ClN10O14PS

Molecular Weight

1257.78

References & Citations

[1]Phillip CC Liu, et al. A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers. Blood. Volume 138, Supplement 1, 23 November 2021, Page 1865