EMD 53998

EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias[1].

Product Specifications

CAS Number

[120223-04-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/emd-53998.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(OC)=C(OC)C=C1)N2C3=CC=C(C(C(S4)C)=NNC4=O)C=C3CCC2

Molecular Formula

C22H23N3O4S

Molecular Weight

425.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Lues I, et al., The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol. 1993 Jun;21 (6) :883-92. |[2]Uhlmann R, et al. EMD 53998 acts as Ca (2+) -sensitizer and phosphodiesterase III-inhibitor in human myocardium. Basic Res Cardiol. 1995 Sep-Oct;90 (5) :365-71.