EMD 53998
Product Specifications
UNSPSC Description
EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias[1].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/emd-53998.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(OC)=C(OC)C=C1)N2C3=CC=C(C(C(S4)C)=NNC4=O)C=C3CCC2
Molecular Weight
425.50
References & Citations
[1]Lues I, et al., The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol. 1993 Jun;21(6):883-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106844/EMD-53998-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106844/EMD-53998-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
120223-04-3
Available Sizes
Curated Selection
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