(S) -PI3Kα-IN-4

(S) -PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S) -PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S) -PI3Kα-IN-4 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2322293-84-3]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-pi3kα-in-4.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC)[C@@H](C)CN1C=NC2=C(C=C(C3=CC(NS(=O)(C4=CC=C(F)C=C4Cl)=O)=C(OC)N=C3)C=C2)C1=O

Molecular Formula

C25H23ClFN5O5S

Molecular Weight

560.00

References & Citations

[1]Dong J, et, al. Discovery of 3-Quinazolin-4 (3 H) -on-3-yl-2, N-dimethylpropanamides as Orally Active and Selective PI3Kα Inhibitors. ACS Med Chem Lett. 2020 Jun 10;11 (7) :1463-1469.