MLN8054

MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.

Product Specifications

CAS Number

[869363-13-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MLN8054.html

Purity

99.01

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(NC2=NC3=C(CN=C(C4=C3C=CC(Cl)=C4)C5=C(F)C=CC=C5F)C=N2)C=C1)O

Molecular Formula

C25H15ClF2N4O2

Molecular Weight

476.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Manfredi MG, et al. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A. 2007 Mar 6;104 (10) :4106-11.|[2]Huck JJ, et al. MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Mol Cancer Res. 2010 Mar;8 (3) :373-84.