VU0361737
VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research[1][2].
Product Specifications
CAS Number
1161205-04-4
Product Name Alternative
ML-128
UNSPSC
12352005
Hazard Statement
H302, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU0361737.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=C(OC)C=C1NC(C2=NC=CC=C2)=O
Molecular Formula
C13H11ClN2O2
Molecular Weight
262.69
Precautions
H302, H319
References & Citations
[1]Engers DW, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs) . J Med Chem. 2009 Jul 23;52 (14) :4115-8.|[2]Engers DW, et al. Discovery, synthesis, and structure-activity relationship development of a series of N- (4-acetamido) phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu (4) ) with CNS exposure in rats. J Med Chem. 2011 Feb 24;54 (4) :1106-10.|[3]Jantas D, et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4
Available Sizes
Frequently Asked Questions
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