VU0361737

VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4 PAM), with EC50s of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research[1][2].

Product Specifications

CAS Number

[1161205-04-4]

Product Name Alternative

ML-128

UNSPSC

12352005

Hazard Statement

H302, H319

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/VU0361737.html

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(C=C1)=C(OC)C=C1NC(C2=NC=CC=C2)=O

Molecular Formula

C13H11ClN2O2

Molecular Weight

262.69

Precautions

H302, H319

References & Citations

[1]Engers DW, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs) . J Med Chem. 2009 Jul 23;52 (14) :4115-8.|[2]Engers DW, et al. Discovery, synthesis, and structure-activity relationship development of a series of N- (4-acetamido) phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu (4) ) with CNS exposure in rats. J Med Chem. 2011 Feb 24;54 (4) :1106-10.|[3]Jantas D, et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124-37.