MTEP (hydrochloride)
MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research[1][2][3][4].
Product Specifications
CAS Number
1186195-60-7
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MTEP-hydrochloride.html
Concentration
10mM
Purity
99.79
Solubility
H2O : 20 mg/mL (ultrasonic)
Smiles
CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl
Molecular Formula
C11H9ClN2S
Molecular Weight
236.72
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Citation 01
Neurochem Int. 2024 Jun 4:178:105786.|Sci Adv. 2022 Aug 19;8 (33) :eabn7357.|Psychopharmacology (Berl) . 2024 Jul;241 (7) :1399-1415.
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