JH-XVI-178
JH-XVI-178 is a highly efficient and selective CDK8/19 inhibitor, with IC50 values of 1 and 2 nM for CDK8 and CDK19, respectively. JH-XVI-178 has a low clearance rate and moderate oral pharmacokinetic properties[1].
Product Specifications
CAS Number
[2648453-53-4]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jh-xvi-178.html
Purity
98.87
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
ClC1=NNC2=NC=C(C3=CC(C=NN4C)=C4C=C3)C(N5CCC6(CCNC6=O)CC5)=C21
Molecular Formula
C22H22ClN7O
Molecular Weight
435.91
References & Citations
[1]Hatcher JM, et al. Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett. 2021 Oct 22;12 (11) :1689-1693.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK19; CDK8
Available Sizes
Curated Selection
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