TDHL

TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

Product Specifications

CAS Number

[37686-84-3]

Product Name Alternative

Tergurid; Terguride; trans-Dihydrolisuride

UNSPSC

12352005

Hazard Statement

H301, H311, H331

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TDHL.html

Purity

99.9

Solubility

10 mM in DMSO

Smiles

CN1[C@@]2([H])[C@@](C[C@@H](C1)NC(N(CC)CC)=O)([H])C3=CC=CC4=C3C(C2)=CN4

Molecular Formula

C20H28N4O

Molecular Weight

340.46

Precautions

H301, H311, H331

References & Citations

[1]Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340 (2) :369-76.|[2]Mizokawa T, et al. Terguride as a new anti-hyperprolactinemic agent: characterization in rats and dogs in comparison with bromocriptine. Jpn J Pharmacol. 1993 Nov;63 (3) :269-78.