ZD-4190
ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.
Product Specifications
CAS Number
413599-62-9
UNSPSC
12352005
Target
EGFR; VEGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ZD-4190.html
Concentration
10mM
Purity
98.08
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(NC3=CC=C(Br)C=C3F)N=CN=C2C=C1OCCN4N=NC=C4
Molecular Formula
C19H16BrFN6O2
Molecular Weight
459.27
References & Citations
[1]Yang M, et al. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imaging. 2011 Jul;38 (7) :1237-47. doi: 10.1007/s00259-011-1742-z. Epub 2011 Mar 1.|[2]Gaballah K, et al. The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues. Br J Cancer. 2009 Aug 4;101 (3) :418-23. doi: 10.1038/sj.bjc.6605092. Epub 2009 Jul 21.|[3]Checkley D, et al. Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Magn Reson Imaging. 2003 Jun;21 (5) :475-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; VEGFR2/KDR/Flk-1
Available Sizes
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