MTR-106
MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer[1].
Product Specifications
CAS Number
1639357-93-9
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; G-quadruplex
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtr-106.html
Purity
99.40
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CN=C(C=N1)CNC(C2=C3N(C4=CC=CC=C4S3)C5=NC(N6C[C@]7([H])[C@](CN(C7)C)([H])C6)=CC=C5C2=O)=O
Molecular Formula
C28H27N7O2S
Molecular Weight
525.62
References & Citations
[1]Li MZ, et, al. Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers. Invest New Drugs. 2021 Oct;39 (5) :1213-1221.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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