NSC 625987

NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].

Product Specifications

CAS Number

[141992-47-4]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-625987.html

Purity

98.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C1C2=C(C=CC=C2)NC3=C(OC)C=CC(OC)=C13

Molecular Formula

C15H13NO2S

Molecular Weight

271.33

References & Citations

[1]A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5 (12) :4279-86.|[2]Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8 (10) :e76183.