5-LOX-IN-1

5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation[1].

Product Specifications

CAS Number

[55040-82-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Lipoxygenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/5-lox-in-1.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C2=CC=CC=C2)N=C(N3CCOCC3)S1)C4=CC=CC=C4

Molecular Formula

C20H18N2O2S

Molecular Weight

350.43

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Sinha S, et al. Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase. Eur J Med Chem. 2018 Oct 5;158:34-50.