NMDAR antagonist 1
NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].
Product Specifications
CAS Number
[2220162-06-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmdar-antagonist-1.html
Purity
99.02
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCCC1=CC=C(O)C=C1)[C@@H]2CCC3=NC4=CC=C(Br)C=C4CN32
Molecular Formula
C20H20BrN3O2
Molecular Weight
414.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang L, et al. Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. Eur J Med Chem. 2018 May 10;151:27-38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
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