NMDAR antagonist 1

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].

Product Specifications

CAS Number

[2220162-06-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nmdar-antagonist-1.html

Purity

99.02

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCCC1=CC=C(O)C=C1)[C@@H]2CCC3=NC4=CC=C(Br)C=C4CN32

Molecular Formula

C20H20BrN3O2

Molecular Weight

414.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang L, et al. Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. Eur J Med Chem. 2018 May 10;151:27-38.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

Available Sizes

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