GDP-L-fucose

GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway. GDP-L-fucose is associated with diabetes in rats[1][2].

Product Specifications

CAS Number

[15839-70-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/gdp-l-fucose.html

Purity

99.82

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(O)(OP(O)(O[C@@H]4[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O4)=O)=O)O3)=C2N=C(N)N1

Molecular Formula

C16H25N5O15P2

Molecular Weight

589.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Weiyang Wang, et al. Cell-free enzymatic synthesis of GDP-L-fucose from mannose. AMB Express. 2019 May 27;9 (1) :74.|[2]1. Wiese TJ, et al. Effect of L-fucose and D-glucose concentration on L-fucoprotein metabolism in human Hep G2 cells and changes in fucosyltransferase and alpha-L-fucosidase activity in liver of diabetic rats. Biochim Biophys Acta. 1997 Apr 17;1335 (1-2) :61-72.