AXC-715 (hydrochloride)
AXC-715 (T785) hydrochloride is a TLR7/TLR8 dual agonist. AXC-715 can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2].
Product Specifications
CAS Number
[2490497-93-1]
Product Name Alternative
T785 (hydrochloride)
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/axc-715-hydrochloride.html
Purity
99.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NCCCCN1C(CCCC)=NC2=C1C3=CC=CC=C3N=C2N.[H]Cl
Molecular Formula
C18H26ClN5
Molecular Weight
347.89
References & Citations
[1]Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. Patent WO2020168017A1|[2]Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. Patent WO2020190734A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8
Available Sizes
Curated Selection
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