AXC-715 (hydrochloride)

AXC-715 (T785) hydrochloride is a TLR7/TLR8 dual agonist. AXC-715 can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2].

Product Specifications

CAS Number

[2490497-93-1]

Product Name Alternative

T785 (hydrochloride)

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/axc-715-hydrochloride.html

Purity

99.46

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NCCCCN1C(CCCC)=NC2=C1C3=CC=CC=C3N=C2N.[H]Cl

Molecular Formula

C18H26ClN5

Molecular Weight

347.89

References & Citations

[1]Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. Patent WO2020168017A1|[2]Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. Patent WO2020190734A1.