HN37

HN37 as a potent and chemically stable antiepileptic agent candidate, with an EC50 of 37 nM for KCNQ2[1]. HN37 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1821222-10-9]

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hn37.html

Concentration

10mM

Purity

99.53

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C(CN(CC#C)C2=CC(C)=C(NC(OC)=O)C(C)=C2)C=C1

Molecular Formula

C20H21FN2O2

Molecular Weight

340.39

References & Citations

[1]Yang-Ming Zhang, et al. Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. J Med Chem. 2021 May 13;64 (9) :5816-5837.