S3969
S3969 is a potent and reversible activator of the human epithelial sodium channel (hENaC) . The apparent EC50 for S3969 activation of hENaC is 1.2 μm[1].
Product Specifications
CAS Number
1027997-01-8
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s3969.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)CC(SC1=CNC2=C1C(C)=CC=C2)C(NCCO)=O
Molecular Formula
C17H24N2O2S
Molecular Weight
320.45
References & Citations
[1]Min Lu, et al. Small molecule activator of the human epithelial sodium channel. J Biol Chem. 2008 May 2;283 (18) :11981-94.|[2]Regina Huber, et al. Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cell Physiol Biochem. 2010;25 (1) :145-58.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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