RUSKI-201
Product Specifications
UNSPSC Description
RUSKI-201 is a potent and specific Hedgehog acyltransferase (Hhat) inhibitor, with an IC50 of 0.20 μM. RUSKI-201 is able to block Hh signaling from Shh overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 is potential Hhat chemical probe in cells and can used in studies of Hhat catalytic function[1].
Target Antigen
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ruski-201.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCC(C)CNCC(N1CCC2=C(C=CS2)C1C3=NC(C)=CC=C3)=O
Molecular Weight
357.51
References & Citations
[1]Ursula R Rodgers, et al. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123781/RUSKI-201-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123781/
Clinical Information
No Development Reported
CAS Number
1458031-48-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7008096-01 0.02 mg
Recombinant Yersinia pseudotuberculosis serotype O:3 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
Ask
View Details MBS7008096-02 0.1 mg
Recombinant Yersinia pseudotuberculosis serotype O:3 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
Ask
View Details 
MBS7008096-03 5x 0.1 mg
Recombinant Yersinia pseudotuberculosis serotype O:3 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase (arnC)
Ask
View Details