Indantadol (hydrochloride)
Indantadol hydrochloride (CHF-3381) is an orally active, non-selective NMDA antagonist and MAO inhibitor. Indantadol hydrochloride blocks the binding of [³H]-MK-801 to NMDA receptors in a non-competitive manner, with an IC50 of 8.1 μM. Indantadol hydrochloride completely inhibits dopamine release caused by NMDA. Indantadol hydrochloride protects neurons, with an ED₅₀ of 35 μM. Indantadol hydrochloride has anticonvulsant and anti-high pain hypersensitivity activities[1][2][3].
Product Specifications
CAS Number
202914-18-9
Product Name Alternative
CHF-3381
UNSPSC
12352005
Target
IGluR; Monoamine Oxidase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/indantadol-hydrochloride.html
Smiles
O=C(CNC1CC2=C(C1)C=CC=C2)N.Cl
Molecular Formula
C11H15ClN2O
Molecular Weight
226.70
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
MEK1 (Dual Specificity Mitogen-Activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAPKK 1, MKK1, ERK Activator Kinase 1, MAPK/ERK Kinase 1, MEK 1, MAP2K1, MEK-1, PRKMK1) discontinued
MEK1 (Dual Specificity Mitogen-Activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAPKK 1, MKK1, ERK Activator Kinase 1, MAPK/ERK Kinase 1, MEK 1, MAP2K1, MEK-1, PRKMK1) discontinued
