JAK-IN-26
JAK-IN-26 (Compound 2) is a JAK inhibitor. JAK-IN-26 inhibits IFN-α2b induced p-STAT3 in Jurkat cells (IC50: 17.2 nM) . JAK-IN-26 has superior pharmacokinetic properties[1].
Product Specifications
CAS Number
2417134-93-9
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak-in-26.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1CC1)NC2=NC=C(C(NC3=CC=CC(C4=NN(C)C=N4)=C3OC)=C2)C(CC)=O
Molecular Formula
C22H24N6O3
Molecular Weight
420.46
References & Citations
[1]Zhou M, et al. Pyridine derivatives as TYK2 kinase inhibitors and preparation thereof. China, CN113563309 A 2021-10-29.|[2]Zhou Mengguang. Pyridine derivative and preparation method and application thereof. Patent. CN113563309.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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