Pheniramine

Pheniramine (Prophenpyridamine; Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects[1][2][3][4].

Product Specifications

CAS Number

[86-21-5]

Product Name Alternative

Prophenpyridamine; Tripoton; Pheniramine solution

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Apoptosis; Histamine Receptor

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pheniramine.html

Solubility

10 mM in DMSO

Smiles

CN(CCC(C1=CC=CC=N1)C2=CC=CC=C2)C

Molecular Formula

C16H20N2

Molecular Weight

240.34

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sharma A, et al. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. Curr Drug Metab. 2003 Apr;4 (2) :105-29.|[2]Brown RD, et al. Alpha 1-adrenergic and H1-histamine receptor control of intracellular Ca2+ in a muscle cell line: the influence of prior agonist exposure on receptor responsiveness. Mol Pharmacol. 1986 Jun;29 (6) :531-9.|[3]Jangi SM, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14 (7-8) :363-72.|[4]Hung CH, et al. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673 (1-3) :20-4.