Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Hydrocotarnine

Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research[1][2][3].

Product Specifications

CAS Number

550-10-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E1/E2/E3 Enzyme; Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hydrocotarnine.html

Purity

99.70

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CN1CCC2=CC3=C(C(=C2C1)OC)OCO3

Molecular Formula

C12H15NO3

Molecular Weight

221.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Chung IC, et al. Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation. Cell Death Dis. 2018 Oct 31;9 (11) :1109. |[2]Lin HC, et al. Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition. Int J Mol Sci. 2020 Jul 19;21 (14) :5104. |[3]Kim KU, et al. DITMD-induced mitotic defects and apoptosis in tumor cells by blocking the polo-box domain-dependent functions of polo-like kinase 1. Eur J Pharmacol. 2019 Mar 15;847:113-122.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Histone H1 (AE-4), CF405S conjugate, 0.1mg/mL
BNC040096-100 1x 100 µL

Histone H1 (AE-4), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
U2AF1L3 (U2AF1L4) Mouse Monoclonal Antibody [Clone ID: OTI8B1]
CF810435 100 µg

U2AF1L3 (U2AF1L4) Mouse Monoclonal Antibody [Clone ID: OTI8B1]

Sign In for Pricing
View Details
SMC1 (SMC1A) Rabbit Polyclonal Antibody
AP02703PU-N 100 µL

SMC1 (SMC1A) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
N6-[(Allylamino]carbonothioyl]lysine-13C6,15N2
TRC-A614227-1MG 1 mg

N6-[(Allylamino]carbonothioyl]lysine-13C6,15N2

Sign In for Pricing
View Details
n-Butyl 4-Hydroxybenzoate-2,3,5,6-d4
TRC-B693604-5MG 5 mg

n-Butyl 4-Hydroxybenzoate-2,3,5,6-d4

Sign In for Pricing
View Details
ADIG (NM_001018082) Human Recombinant Protein
TP306940M 100 µg

ADIG (NM_001018082) Human Recombinant Protein

Sign In for Pricing
View Details