SHP2-IN-25
SHP2-IN-25 (Compound 6) is a SHP2 allosteric inhibitor, with an IC50 of 225 nM. SHP2-IN-25 can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-25.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=NC=CC=C1SC2=NC3=C(N=C2)NC(NC[C@@H](CN4)C[C@H]4C5=CC=CC=C5)=N3
Molecular Formula
C22H20F3N7S
Molecular Weight
471.50
References & Citations
[1]Ponzi S, et al. Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors. Bioorg Med Chem Lett. 2024 Mar 1;100:129626.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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