Repinotan (hydrochloride)

Repinotan hydrochloride (BAY x 3702) is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride has pronounced neuroprotective effects[1].

Product Specifications

CAS Number

[144980-77-8]

Product Name Alternative

BAY x 3702

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/repinotan-hydrochloride.html

Purity

97.08

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=C1)N(CCCCNC[C@H]3CCC4=CC=CC=C4O3)S2(=O)=O.[H]Cl

Molecular Formula

C21H25ClN2O4S

Molecular Weight

436.95

References & Citations

[1]A C Berends, et al. A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke. CNS Drug Rev. Winter 2005;11 (4) :379-402.