Crocetin monomethyl ester

Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity[1][2]. Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway[4].

Product Specifications

CAS Number

[25368-09-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319

Target

Amyloid-β

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/crocetin-monomethyl-ester.html

Purity

98.44

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

OC(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(OC)=O)=O

Molecular Formula

C21H26O4

Molecular Weight

342.43

Precautions

H302, H315, H319

References & Citations

[1]Tseng TH, et al. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 1995 Oct 20;97 (1) :61-7.|[2]Ahmad AS, et al. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav. 2005 Aug;81 (4) :805-13.|[3]Nam KN, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010 Dec 1;648 (1-3) :110-6.|[4]Wani A, Al Rihani SB, Sharma A, et al. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021;17 (11) :3813-3832.