AFMK

AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity[1][2]. AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway[3].

Product Specifications

CAS Number

[52450-38-1]

UNSPSC

12352005

Hazard Statement

H301

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/afmk.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(NCCC(C1=CC(OC)=CC=C1NC=O)=O)=O

Molecular Formula

C13H16N2O4

Molecular Weight

264.28

Precautions

H301

References & Citations

[1]Annia Galano, et al. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res. 2013 Apr;54 (3) :245-57.|[2]Kailash Manda, et al. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res. 2007 Apr;42 (4) :386-93.|[3]Anna Leja-Szpak, et al. Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1) . Pharmacol Rep. 2018 Dec;70 (6) :1079-1088.