AFMK
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity[1][2]. AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway[3].
Product Specifications
CAS Number
52450-38-1
UNSPSC
12352005
Hazard Statement
H301
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/afmk.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(NCCC(C1=CC(OC)=CC=C1NC=O)=O)=O
Molecular Formula
C13H16N2O4
Molecular Weight
264.28
Precautions
H301
References & Citations
[1]Annia Galano, et al. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res. 2013 Apr;54 (3) :245-57.|[2]Kailash Manda, et al. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res. 2007 Apr;42 (4) :386-93.|[3]Anna Leja-Szpak, et al. Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1) . Pharmacol Rep. 2018 Dec;70 (6) :1079-1088.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Polyclonal CORO2A Antibody [Alexa Fluor 405]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-99188AF405 0.1 mL
Rabbit Polyclonal CORO2A Antibody [Alexa Fluor 405]
Sign In for Pricing
View Details 
A05556-Dylight488 100 µg
Anti-DYNLT1 Antibody Picoband® (Dylight488 Conjugate)
Sign In for Pricing
View Details