Clascoterone
Clascoterone (Cortexolone 17 alpha-propionate; Cortexolone 17α-propionate; CB-03-01) is a new topical and peripherally selective androgen antagonist.
Product Specifications
CAS Number
19608-29-8
Product Name Alternative
Cortexolone 17 alpha-propionate; Cortexolone 17α-propionate; CB-03-01
UNSPSC
12352211
Hazard Statement
H315, H319, H320
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Cortexolone-17-alpha-propionate.html
Purity
98.53
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4(C(CO)=O)OC(CC)=O)=C1
Molecular Formula
C24H34O5
Molecular Weight
402.52
Precautions
H315, H319, H320
References & Citations
[1]Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165 (1) :177-83.|[2]Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54 (12) :881-6.|[3]Trifu V, et al. Cortexolone 17-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 005% cream. Br J Dermatol. 2011 Jul;165 (1) :177-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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