8-NBD-cAMP (sodium)

8-NBD-cAMP sodium is a fluorescently labeled cyclic adenosine phosphate (cAMP) analogue. 8-NBD-cAMP sodium retains a similar biological activity to cAMP, regulating their activity by binding to specific proteins such as EPACs or PKA. 8-NBD-cAMP sodium can be used in fluorescent competitive binding experiments to evaluate the binding affinity of newly synthesized EPAC1 agonists to EPAC1 proteins[1].

Product Specifications

CAS Number

[221905-51-7]

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/8-nbd-camp-sodium.html

Smiles

NC1=C(N=C2SCCNC3=CC=C([N+]([O-])=O)C4=NON=C43)C(N2[C@@]5([H])[C@H](O)[C@@](OP(OC6)(O[Na])=O)([H])[C@]6([H])O5)=NC=N1

Molecular Formula

C18H17N9NaO9PS

Molecular Weight

589.41

References & Citations

[1]Wang P, et al. Synthesis and biochemical evaluation of noncyclic nucleotide exchange proteins directly activated by cAMP 1 (EPAC1) regulators[J]. Journal of medicinal chemistry, 2020, 63 (10) : 5159-5184.