Maprotiline (hydrochloride)

Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].

Product Specifications

CAS Number

[10347-81-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; ERK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/maprotiline-hydrochloride.html

Purity

99.98

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.2 mg/mL (ultrasonic)

Smiles

CNCCCC1(CC2)C3=CC=CC=C3C2C4=CC=CC=C14.Cl

Molecular Formula

C20H24ClN

Molecular Weight

313.86

Precautions

H302

References & Citations

[1]Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767.|[2]Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20 (3) :465-71.