NCB-0970

NCB-0970 is the negative control of NCB-0846 (HY-100830) . NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation[1][2].

Product Specifications

CAS Number

[2749881-54-5]

UNSPSC

12352005

Target

MAP4K; TGF-beta/Smad; Wnt

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ncb-0970.html

Purity

98.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H](CC1)CC[C@@H]1OC2=CC=CC3=C2N=C(NC4=CC=C(N=CN5)C5=C4)N=C3

Molecular Formula

C21H21N5O2

Molecular Weight

375.42

References & Citations

[1]Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586. |[2]Sugano T, et al., Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846. Br J Cancer. 2021 Jan;124 (1) :228-236.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP4K7/TNIK

Available Sizes

Curated Selection

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