KRAS G12C inhibitor 15
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM[1].
Product Specifications
CAS Number
[2349393-21-9]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-15.html
Purity
98.47
Solubility
DMSO : 193.33 mg/mL (ultrasonic)
Smiles
FC1=C(N=CC(N2C)=C3N4[C@H](CN(C(C=C)=O)[C@H](C)C4)C2=O)C3=CC(Cl)=[C@@]1[C@@]5=C(F)C=CC=C5O
Molecular Formula
C25H21ClF2N4O3
Molecular Weight
498.91
References & Citations
[1]Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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