WHI-P154

WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.

Product Specifications

CAS Number

[211555-04-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; EGFR; JAK

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WHI-P154.html

Purity

98.77

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br

Molecular Formula

C16H14BrN3O3

Molecular Weight

376.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Changelian PS, et al. The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111 (4) :2155-7. Epub 2007 Dec 19.|[2]Zhang H, et al. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci. 2014 Aug;105 (8) :1071-8.