WHI-P154
WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.
Product Specifications
CAS Number
[211555-04-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; EGFR; JAK
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WHI-P154.html
Purity
98.77
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1Br
Molecular Formula
C16H14BrN3O3
Molecular Weight
376.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Changelian PS, et al. The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111 (4) :2155-7. Epub 2007 Dec 19.|[2]Zhang H, et al. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci. 2014 Aug;105 (8) :1071-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; JAK3
Available Sizes
Curated Selection
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