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Ciclopirox (olamine) (Standard)

Ciclopirox (olamine) (Standard) is the analytical standard of Ciclopirox (olamine) . This product is intended for research and analytical applications. Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect[1][2][3].

Product Specifications

CAS Number

41621-49-2

Product Name Alternative

Ciclopirox (ethanolamine) (Standard) ; HOE 296 (Standard)

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Bacterial; Ferroptosis; Fungal; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Others

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/ciclopirox-olamine-standard.html

Smiles

O=C1C=C(C)C=C(C2CCCCC2)N1O.NCCO

Molecular Formula

C14H24N2O3

Molecular Weight

268.35

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Niewerth M, et al. Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother. 2003 Jun;47 (6) :1805-17.|[2]Leem, S.H., et al., The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae. Mol Cells, 2003. 15 (1) : p. 55-61.|[3]Ratnavel, R.C., R.A. Squire, and G.C. Boorman, Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis. J Dermatolog Treat, 2007. 18 (2) : p. 88-96.|[4]Clement PM, et al. The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro. Int J Cancer. 2002 Aug 1;100 (4) :491-8.|[5]Lu J, et al. Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells. Cell Commun Signal. 2022 Mar 24;20 (1) :37.|[6]Zhou H, et al. The antitumor activity of the fungicide ciclopirox. Int J Cancer. 2010 Nov 15;127 (10) :2467-77.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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