10β,17β-dihydroxyestra-1,4-dien-3-one
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor proagent of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].
Product Specifications
CAS Number
549-02-0
Product Name Alternative
DHED
UNSPSC
12352211
Hazard Statement
H360
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/10-beta-17-beta-dihydroxyestra-1-4-dien-3-one.html
Concentration
10mM
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(O)[C@@]3([H])CC2)=O
Molecular Formula
C18H24O3
Molecular Weight
288.39
Precautions
H360
References & Citations
[1]Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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