10β,17β-dihydroxyestra-1,4-dien-3-one

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor proagent of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].

Product Specifications

CAS Number

[549-02-0]

Product Name Alternative

DHED

UNSPSC

12352211

Hazard Statement

H360

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/10-beta-17-beta-dihydroxyestra-1-4-dien-3-one.html

Concentration

10mM

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(O)[C@@]3([H])CC2)=O

Molecular Formula

C18H24O3

Molecular Weight

288.39

Precautions

H360

References & Citations

[1]Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.