17 (R) -Resolvin D1

17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells[1]. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC50 of 398 nM and exhibits peripheral anti-nociceptive efficacy[2].

Product Specifications

CAS Number

[528583-91-7]

Product Name Alternative

17 (R) -RvD1; AT-RvD1

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/17-r-resolvin-d1.html

Concentration

265.61 μM * 100 μL in Ethanol

Purity

99.1

Solubility

10 mM in DMSO

Smiles

CC/C=C\C[C@@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O

Molecular Formula

C22H32O5

Molecular Weight

376.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Sun YP, et al., Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282 (13) :9323-9334.|[2]Bang S, et al., 17 (R) -resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165 (3) :683-92.