Recombinant Human Pleiotrophin protein (PTN) (Active)
Product Specifications
Background
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.
Product Name Alternative
PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule
Gene ID
5764
UniProt
P21246
Target
GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
Purification
>96% as determined by SDS?PAGE and HPLC.
Bioactivity
Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16?E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre?coated with 100 ?l, well of a solution of 5?10 ?g, ml rHuPTN.
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Calculated Molecular Weight
15.3 kDa
Formulation
0.2 m filtered PBS, pH 7.4 , lyophilized
Host or Source
E.Coli
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