β-Amyrin

β-Amyrin shows effectively counteract amyloid β (Aβ) -induced impairment of long-term potentiation (LTP) . β-Amyrin is a promising candidate for Alzheimer's disease (AD) research. β-Amyrin exhibits anti-inflammatory effects, protective activity against pulmonary fibrosis, and notable antibacterial capabilities. β-Amyrin is an orally active natural triterpenoid compound[1][2][3][4].

Product Specifications

CAS Number

[559-70-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; NF-κB

Type

Natural Products

Related Pathways

Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/beta-amyrin.html

Purity

99.95

Solubility

Ethanol : 5 mg/mL (ultrasonic)

Smiles

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]

Molecular Formula

C30H50O

Molecular Weight

426.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Park HJ, et al. β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus. Biomol Ther (Seoul) . 2019 Jul 30. |[2]Krishnan K, et al. Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus. Inflammopharmacology. 2014 Dec;22 (6) :373-85. |[3] Cai Z, Liu J, et al. β-Amyrin ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress in mice. Pak J Pharm Sci. 2023 Mar;36 (2) :431-436.|[4]Han G, et al. Antibacterial Mode of Action of β-Amyrin Promotes Apoptosis-Like Death in Escherichia coli by Producing Reactive Oxygen Species. J Microbiol Biotechnol. 2022 Dec 28;32 (12) :1547-1552. |[5]Ching J, et al. Quantification of α- and β-amyrin in rat plasma by gas chromatography-mass spectrometry: application to preclinical pharmacokinetic study. J Mass Spectrom. 2011 May;46 (5) :457-64.