4-Thio-2’-deoxyuridine
4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[5580-20-1]
Product Name Alternative
2′-Deoxy-4-thiouridine; 4-Thiodeoxyuridine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-thio-2-deoxyuridine.html
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](N2C(NC(C=C2)=S)=O)O[C@@H]1CO
Molecular Formula
C9H12N2O4S
Molecular Weight
244.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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