Thio-TEPA

Thio-TEPA is a DNA alkylating agent, with antitumor activity.

Product Specifications

CAS Number

[52-24-4]

UNSPSC

12352005

Hazard Statement

H300, H350

Target

Antibiotic; Bacterial; DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Thio-TEPA.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

Smiles

S=P(N1CC1)(N2CC2)N3CC3

Molecular Formula

C6H12N3PS

Molecular Weight

189.22

Precautions

H300, H350

References & Citations

[1]Hagen B, et al. Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation. Cancer Chemother Pharmacol. 1991;28 (6) :441-7.|[2]Down JD, et al. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice. Bone Marrow Transplant. 1998 Feb;21 (4) :327-30.