Thio-TEPA
Thio-TEPA is a DNA alkylating agent, with antitumor activity.
Product Specifications
CAS Number
52-24-4
UNSPSC
12352005
Hazard Statement
H300, H350
Target
Antibiotic; Bacterial; DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Thio-TEPA.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
S=P(N1CC1)(N2CC2)N3CC3
Molecular Formula
C6H12N3PS
Molecular Weight
189.22
Precautions
H300, H350
References & Citations
[1]Hagen B, et al. Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation. Cancer Chemother Pharmacol. 1991;28 (6) :441-7.|[2]Down JD, et al. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice. Bone Marrow Transplant. 1998 Feb;21 (4) :327-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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