Coralyne (chloride)

Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes[3].

Product Specifications

CAS Number

[38989-38-7]

Product Name Alternative

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

UNSPSC

12352005

Hazard Statement

H301, H413

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/coralyne-chloride.html

Purity

98.30

Solubility

DMSO : 1.82 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C2C=C(C(OC)=CC2=CC3=C4C=C(C(OC)=CC4=CC=[N+]13)OC)OC.[Cl-]

Molecular Formula

C22H22ClNO4

Molecular Weight

399.87

Precautions

H301, H413

References & Citations

[1]Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445.|[2]D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4 (6) :781-91.|[3]P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7 (18) :10660-10667.