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Heme Oxygenase-1-IN-1 (hydrochloride)

Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM[1].

Product Specifications

CAS Number

1092851-70-1

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ho-1-in-1-hydrochloride.html

Purity

99.03

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

BrC1=CC=C(CCCCN2C=CN=C2)C=C1.Cl

Molecular Formula

C13H16BrClN2

Molecular Weight

315.64

References & Citations

[1]Floresta G, et al. Development of new HO-1 inhibitors by a thorough scaffold-hopping analysis. Bioorg Chem. 2018 Dec;81:334-339.|[2]Zeng X, et al. Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3) -mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1 (HO-1) -NF-кB axis. Free Radic Biol Med. 2023 Jun;202:46-61. |[3]Wang X, et al. Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop. Gastric Cancer. 2021 Jan;24 (1) :117-132.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Arch Oral Biol. 2025 Oct:178:106364.|Cell Death Dis. 2022 Sep 26;13 (9) :822.|Free Radic Biol Med. 2023 Mar 27;202:46-61.|Front Oncol. 2021 May 26:11:679816.|Front Oncol. 2021 Sep 24:11:728047.|J Dent Sci. 2025 Nov 1.|Nitric Oxide. 2022 Dec 1:129:41-52.|Int Immunopharmacol. 2026 Jan 1;168 (Pt 1) :115795.|J Clin Invest. 2024 Dec 2;134 (23) :e181044.|Mar Drugs. 2025 Mar 12;23 (3) :123.

Available Sizes

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