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Val-Cit-PAB-Exatecan

Product Specifications

UNSPSC Description

Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker[1].

Target Antigen

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/val-cit-pab-exatecan.html

Solubility

10 mM in DMSO

Smiles

CC(C)[C@H](N)C(N[C@@H](CCCNC(N)=O)C(NC(C=C1)=CC=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O

Molecular Weight

840.90

References & Citations

[1]Thomas A, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.

Shipping Conditions

Blue Ice

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-153031/Val-Cit-PAB-Exatecan-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-153031/Val-Cit-PAB-Exatecan-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2227350-99-2

Available Sizes

Curated Selection

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